Creative Diagnostics, a leading manufacturer and supplier of antibodies, antigens and assay kits, has announced the launch of its Hantavirus Research Reagents and Products to support hantavirus research and diagnostic assay development. This comprehensive catalog aims to help academic researchers, biopharmaceutical companies, and industrial organizations accelerate the development of diagnostic assays and therapeutic interventions targeting dangerous rodent-borne orthohantaviruses.
Hantaviruses are emerging zoonotic pathogens belonging to the Bunyaviridae family. The US Centers for Disease Control and Prevention (CDC) classifies them as Category A pathogens. They pose a serious threat to human health as infection can lead to hemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS), both of which are highly fatal. These pathogens are transmitted to humans via aerosols containing the excreta of infected rodent hosts.
Hantaviruses possess a tripartite negative-strand RNA genome. The three genomic RNA segments (S, M and L) encode the nucleocapsid protein (N), a precursor glycoprotein (which forms two envelope glycoproteins, Gn and Gc upon processing), and the viral RNA-dependent RNA polymerase (RdRp). The N protein is the virus's primary structural component, protecting and encapsulating the three genomic RNA strands to form three viral ribonucleocapsids. Recent studies suggest that the N protein acts in concert with RdRp to play a crucial role in transcription and replication of the viral genome, and it preferentially promotes translation of viral mRNA within the cell.
Currently, no antiviral therapies or vaccines are available to treat hantavirus-associated diseases. A deeper understanding of the molecular mechanisms underlying the hantavirus life cycle could help identify targets for antiviral therapy and design potential drugs to treat HFRS and HCPS. Given the alarming case-fatality rate of hantavirus diseases, development of an effective hantavirus vaccine is imperative. As early clinical manifestations of hantavirus infection often resemble common seasonal respiratory or influenza-like illnesses, there is an urgent need for highly sensitive, reliable and standardized laboratory diagnostic tools to enable early differential diagnosis and accurate target validation.
To address these research challenges, Creative Diagnostics offers a range of hantavirus research reagents and products covering multiple strains, including Hantavirus, Puumala virus (PUUV), Seoul virus (SEOV) and Sin Nombre virus (SNV). The new product line includes: 1) Recombinant hantavirus antigens for assay development; 2) high-affinity monoclonal and polyclonal antibodies validated for capture and detection uses across multiple platforms, including Western blot, flow cytometry, immunohistochemistry and surface plasmon resonance; 3) supporting reagents for ELISA and rapid immunoassay research.
For detailed product specifications, volume pricing, or to browse the complete list of available viral solutions, please visit the official product portal at https://www.creative-diagnostics.com/hantavirus.htm.
