Sino Biological, Inc. (Shenzhen Stock Exchange: 301047.SZ) has launched the XPressMAX™ Cell-Free Protein Synthesis Kit (Cat#: CFKIT02), a novel tool designed to accelerate AI-powered high-throughput screening for antibody drug discovery. The kit utilizes advanced cell-free protein synthesis technology to produce target proteins and antibodies rapidly in vitro, bypassing the constraints of traditional cell-based expression systems. By integrating with AI screening platforms, it aims to speed up the identification and optimization of antibody candidates while reducing development costs.
Based on an E. coli lysate supplemented with essential transcription and translation components, XPressMAX™ allows direct protein synthesis from plasmid or PCR templates. It is specifically designed for antibody drug discovery, enabling rapid expression and validation of VHH, scFv, Fab, and miniproteins. Sino Biological has used the kit to establish a high-throughput cell-free expression platform that validates over 2,000 scFv/VHH molecules in 3-4 weeks, matching AI's rapid iteration pace.
Key highlights of XPressMAX™ include ultra-fast synthesis completed in just 3 hours, a success rate greater than 99%, and support for complex disulfide bonding without additional enhancers, ensuring native folding and bioactivity. According to Sino Biological, this combination of speed, reliability, and throughput addresses the growing demand for expression systems that can keep up with AI-driven discovery processes.
“Our XPressMAX™ is a significant advancement in research tools and reagents for next-generation therapeutic discovery,” said Dr. Rob Burgess, Chief Business Officer at Sino Biological US, Inc. “By combining rapid, reliable protein expression with intelligent screening, we are helping our partners compress antibody discovery timelines without compromising quality.” Dr. Jie Zhang, Sino Biological’s General Manager, added, “AI is revolutionizing antibody screening, but it demands expression systems that can match its speed and throughput. XPressMAX™ achieves rapid, high-success expression of challenging proteins in as little as 3 hours.”
Researchers can learn more about XPressMAX™ or request a free sample at Sino Biological's product page. The company also offers a dedicated cell-free expression solutions page at https://www.sinobiological.com/category/solutions/cell-free.
Sino Biological is an international reagent supplier and CRO service provider specializing in recombinant protein production and antibody development. With the US-based Center for Bioprocessing (C4B) in Houston and SignalChem Biotech in Canada, the company delivers tailored solutions to researchers in over 90 countries.
